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When cysteine is deficient due to malnutrition, the -glutamyl cysteine cannot be produced, and glutamic acid is rather transformed into -glutamyl phosphate, which in turn will autocyclize to form the 5-oxoproline

doi: 10.14814/phy2.14651 27 BiswasSCButeauJGreeneLA

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Phase I study of TAS-102 administered once daily on a 5-day-per-week schedule in patients with solid tumors

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Using deep sequencing, 13 peptide sequences with frequency higher than 1% were identified following the third round of selection and considered as hits (Fig