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Acknowledgements We thank everyone involved for their efforts in the writing and critical review of this manuscript

In vivo rodent models have explored tissue-specific IGF-1R engagement by comparing the biodistribution and signalling footprint of IGF-1 LR3 against the native 70-amino acid ligand

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On average, use it for at least 2 to 3 months

We received no comments on our proposed adjustments to paragraphs (b)(1), (e) and (f)