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This has mainly derived from experimental studies, although the first results emerged over 30 years ago with the observation of reduced UA in the substantia nigra of PD patients at post mortem 10

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It consists of a single layer of tightly connected columnar epithelial cells that keep out foreign antigens, microorganisms, and their toxins (62)

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On the other hand, RIPK3 has been shown to regulate hematopoiesis in stress conditions by triggering senescence of HSCs and by promoting MLKL-dependent necroptosis [153, 154]

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