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The mammalian sirtuins (Sirt1--Sirt7) participate in a number of cellular and physiological functions such as gene silencing, apoptosis, mitochondrial function, energy homeostasis, and longevity [237].Transgenic mice with overexpression of the sirt1 gene demonstrate decreased lipid-induced inflammation, improved glucose tolerance, and protection from hepatic steatosis when fed a high-fat diet [238]

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10.1001/archopht.1978.03910050179015 25 HrelecM.KlicekR.BrcicL.BrcicI.CvjetkoI.SeiwerthS.et al (2009)

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545 For example, pelacarsen, an Lp(a) ASO drug developed by Ionis in collaboration with Novartis AG, effectively lowers Lp(a) levels by selectively cleaving Apo(a) gene (LPA) mRNA

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