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For example, GGT is involved in the biosynthesis of the phytoalexin camalexin by removing a -glutamyl group from glutathione-indole-3-acetonitrile in Arabidopsis (Su et al., 2011), in the conversion of the endogenous glutathione S -conjugate leukotriene C4 to leukotriene D4 in rats (Zhang et al., 2005

GIPR:GCGR co-agonism restores normal weight in obese rodents

This means that while the association is clear and the mechanisms are well-hypothesized, definitive answers about causation, dose-response relationships, and optimal prevention remain areas of active investigation

10.1007/s13770-016-9073-6 11 CiapettiG.GranchiD.FotiaC.SavarinoL.DallariD.Del PiccoloN.et al (2016)

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doi: 10.1016/j.jff.2014.12.018