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Traditional weight loss drugs often limit their application due to systemic side effects

Peptides might engage with thyroid meds, corticosteroids, insulin or diabetes drugs, growth hormone supplements, and blood-glucose controllers

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If unpleasant effects arise, it is advisable to review dose, timing and rule out interactions, especially if medication is being taken

The trouble was as soon as they would form the 4-membered amide ring (a beta lactam) using conventional conditions the damn thing would fall apart