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However, the number and pace of clinical trials to tackle LC are vastly insufficient (127)

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2) Hormonal interactions: oestrogen may synergise with GLP-1 RAs to enhance appetite regulation by activating brain regions involved in controlling food intake and modifying reward pathways [55, 56]

However, the expression of GPx1 has been reported to be down-regulated in thyroid cancer [44], colorectal cancer [45, 46], and gastric cancer [47], whereas GPx1 has been demonstrated to play an oncogenic role in kidney cancer [48], pancreatic cancer [49], and laryngeal squamous cell carcinoma [50]

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