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The plateau phase begins for most participants around weeks 40 to 48, with an average plateau arrival at week 43.2

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The least-squares mean percentage change in body weight from baseline was -7.2% in the 1 mg group, -12.9% in the 4 mg group (starting at 2 mg), -17.1% in the combined 4 mg groups, -17.5% in the combined 8 mg groups, and -17.5% in the 12 mg group, compared with -1.6% in the placebo group

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These symptoms, while uncomfortable, are part of the normal adaptation process and are consistent with the clinical trial experience

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Clinical teams must expect both physical and emotional effects

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Participants reported a 75.8% reduction in pain on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale

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In this study, Bbs5 / mice showed impaired nest-building behavior (Figure 1F), indicative of potential learning and/or motor deficits

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