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Furthermore, in a paraquat-induced fibrosis model, Xuebijing injection, a traditional Chinese medicine compound, corrected elevated levels of L-valine, glycine, and L-tryptophan, indicating its antifibrotic potential may be related to rebalancing amino acid metabolic disturbances [165]

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Notably, loss-of-function mutations in ABCG2 (e.g., Q141K) impair intestinal urate excretion, thereby significantly increasing the risk of gout ( 2.1.3 Epigenetic reprogramming Recent studies have revealed distinct DNA methylation patterns in patients with gout compared to those with hyperuricemic individuals

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