However, long-term use may increase the risk of squamous cell skin cancer and melanoma (Archier 2012)
as a key regulator of mitochondrial biogenesis, PGC1 enhances mitochondrial function in myoblasts, supplies sufficient energy for differentiation, and regulates the transcription of myogenic genes to accelerate myotube maturation
carried out affinity binding high-throughput screening (HTS) to test in vitro, 1120 FDA-approved small molecules for their ability to a specifically bind to HsrA and inhibit its function
Al Rajabi A 1 , Castro GS, da Silva RP, Nelson RC, Thiesen A, Vannucchi H, Vine DF, Proctor SD, Field CJ, Curtis JM, Jacobs RL
Established therapies should generally be considered first-line treatments unless contraindicated
PLoS ONE 5 , e8547 (2010)