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Prescription weight-loss drugs Zepbound, Semaglutide GLP-1, and Wegovy are intended to assist those who are struggling with weight loss

Washout approach (more common): Administer final Wegovy dose Wait 7 to 10 days (approximately 1.5 half-lives) Start Zepbound 2.5 mg Rationale: minimizes overlapping GLP-1 receptor activation, reduces nausea risk Overlap approach (less common, used when continuous appetite suppression is critical): Administer final Wegovy dose Start Zepbound 2.5 mg 3 to 4 days later Rationale: prevents gap in therapeutic effect during washout Risk: higher nausea and GI side effect burden during overlap window Most providers use washout

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This is why people taking GLP-1 agonists like Wegovy often report feeling satisfied longer after eating and experience reduced food cravings

Beyond physical appearance, the psychological boost from these surgeries can be significant

Schrock AB, Li SD, Frampton GM, et al