The long-term effects of tirzepatide on diabetic retinopathy and diabetic neuropathy remain a topic of considerable debate
Eye problems Rapid improvement in blood sugar may temporarily worsen diabetic retinopathy, an eye condition related to type 1 and type 2 diabetes
and reports other support from Travere Therapeutics Inc, the Doris Duke Charitable Foundation, Bayer AG, AstraZeneca, Novo Nordisk, The George Institute for Global Health, CareDx and KBP BioSciences, and personal fees from Boehringer Ingelheim, Bayer Pharmaceuticals and Eli Lilly
We cover every major GLP-1 drug currently available, how they work, how they compare, who is a good candidate, and critically what makes the difference between dramatic results and disappointing ones
Interestingly, in echidna GLP-1 there is less conservation of the receptor binding residues with additional changes at the N-terminal receptor binding Phe 12 (conservatively substituted to Tyr) and Asp 15 (changed to Glu) residues
It is difficult to distinguish symptoms from FDA-approved and compounded products, Basina noted