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The safest approach is to restart at the lowest dose and titrate up, though this may not be practical for frequent alternating

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Single-peptide therapy tends to produce early improvement because it supports one bottleneck well

7 AoyagiK.KoufujiK.YanoS.MurakamiN.MiyagiM.KogaA.et al (2003)

Both produce over 20% body weight reduction in clinical trials