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For study 2, mice were randomly divided into three experimental groups ( n = 10 mice per group) such that each group had a similar mean body weight and was assigned to receive once-daily s.c

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GLP-1 effects are mediated through binding to the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR) that signals primarily through the stimulatory G protein G s