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Though DAM has been detected across multiple neurological disease models, the composition of disease related microglia and macrophage clusters differs between diseasephagocytic subtype predominant in AD, while inflammatory subtype predominant in ALS (Wishart et al., 2023)

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Local (and systemic) estradiol can stimulate lesion production of PGE2, which can activate pain fibers, enhance neuronal invasion of lesions by stimulating production of NGF and other neurotrophins, and promote sprouting of nociceptors that contribute persistent inflammatory pain and inhibit neuronal apoptosis

doi: 10.1088/0031-9155/25/4/008

Use Modifier 59 when appropriate to differentiate the injections

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