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From a pharmacokinetic perspective, amoxicillin is primarily eliminated unchanged via renal excretion and does not undergo significant hepatic metabolism

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Biochimica Et Biophysica Acta , 1830 (5), 3143-3153

While its efficacy profile is compelling, it remains an investigational compound requiring further long-term safety and regulatory evaluation before widespread clinical adoption

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Its closest structurally characterised homologue is the N domain of the AAA + protein ClpC1 from Mycobacterium tuberculosis (PDB 6PBA), which shares only 17.3% sequence identity 64