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Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial

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Anti-anxiety effects in rats occurred at extremely low doses, producing results within 12 minutes

10.1093/nar/28.1.235 11 BiswasN.ChakrabartiS

While these data formed the basis of early enthusiasm, later peptide clinical trials showed that such results did not translate meaningfully into clinical efficacy