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In the STEP 1 trial (Wilding et al., NEJM 2021), which included adults with obesity or overweight with weight-related comorbidities, participants receiving semaglutide 2.4 mg achieved a mean weight loss of 14.9% compared to 2.4% with placebo over 68 weeks

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Although originally developed for people with type 2 diabetes, semaglutide has also become a popular option for medical weight loss because of how well it supports appetite control and blood sugar regulation

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