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Permanent damage is rare

Significant increase in susceptibility to farnesol in FL3 strain following induction of CDR1 overexpression with the strains lacking the CDR1 gene demonstrating enhanced tolerance

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This pattern aligns with the two-hit model, in which virus-induced inflammation primes the immune system, and subsequent autoantibody-mediated effects drive severe disease progression [119,120,122,123]

Figure 3 illustrates how the network between the gene/pathways and compound targets was built using Cytoscape 3.10.0