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Despite such a great overall efficacy of PDE5i treatment for ED, some limitations exist, mainly attributable to contraindications and to potential adverse effects and related discontinuation of treatment

Each objective, of course, implies a different timeline

doi: 10.1016/B978-0-12-813768-0.00026-8 13 GalanakisCM

Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice

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Notably, lactate production and export to neurons is a key astrocytic function, as lactate supports axonal survival even in oxygen-rich conditions