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Additionally, positive GLP-1R staining was observed in human synovial membrane sections from OA patients, specifically at the intima and blood vessel levels (Fig

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However, the detection window depends heavily on which metabolites are targeted

In patients with OA, levels of C

This reversal was seen also on the background of the disturbed prostaglandins- and NO-systems, prostaglandins synthesis inhibition as well as NO-overstimulation (NOS-substrate L-arginine) or NO-blockade (N(G)-nitro-L-arginine methyl ester (L-NAME)) (Stupnisek et al., 2012

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