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Cell 152(6):123751 Len J, Casado J, Jimnez Ruiz SM, Zurita MS, Gonzlez-Puga C, Rejn JD et al (2014) Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-

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Avoiding eating within 2 hours of bedtime also helps, as lying down with a full stomach can promote acid reflux and morning queasiness