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A critical review

The association between metformin and GDF15 was strengthened by data showing that metformin prevented weight gain in high fat fed mice, but not in mice lacking GDF15, or lacking its receptor, glial cell-derived neurotrophic factor family receptor alpha-like (GFRAL), or following treatment with a GRAL antagonist

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The amine forms a reversible imine with the LTQ (lysine-tyrosylquinone) co-factor in LOXL2

Discontinuation rates due to adverse events were 12.2% at the 9 mg dose and 18.2% at the 12 mg dose in TRIUMPH-4

Rapid weight reduction is a recognized trigger due to abrupt changes in nutrient availability and metabolic demand