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[58] Medical uses [edit] Treatment of deficiency [edit] Severe vitamin B 12 deficiency is initially corrected with daily intramuscular injections of 1000 g of the vitamin, followed by maintenance via monthly injections of the same amount or daily oral dosing of 1000 g

Weeks 12: 2 mg once weekly Weeks 34: 4 mg once weekly Weeks 58: 8 mg once weekly Week 9+: 12 mg once weekly Efficacy and safety: The reason for the slow and gradual dosing protocol The Phase 2 clinical trial of retatrutide demonstrated that participants receiving the highest dose (12 mg) achieved up to 24% weight reduction after 48 weeks