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All weight loss peptides use a slow "titration" approach: you start at a low dose and increase gradually over weeks to minimize side effects (mainly nausea)
Researchers are also exploring new compounds that could help preserve muscle mass during weight loss
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A network meta-analysis published recently confirmed this pattern, finding that retatrutide demonstrated greater absolute weight reduction compared to tirzepatide (retatrutide: MD -16.34 kg vs tirzepatide: MD -11.82 kg)
1 2 Expert Opinion on Pharmacotherapy
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