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J Clin Invest (2004) 113(6):78894

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Cyclooxygenase 2-selective and nonselective nonsteroidal anti-inflammatory drugs induce oxidative stress by up-regulating vascular NADPH oxidases

Overall, extensive experimental evidence demonstrates that estrogen replacement therapies improve skin quality (thickness, elasticity, hydration), accelerate healing, and protect against the development of chronic wounds in aged humans and estrogen-deprived animal models (Ashcroft et al., 1997