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Those with certain medical conditions or who are pregnant should avoid this treatment

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doi: 10.1038/ng0995-45

J Investig Dermatol 133:258267 Chereddy KK, Lopes A, Koussoroplis S, Payen V, Moia C, Zhu H, Sonveaux P, Carmeliet P, des Rieux A, Vandermeulen G, Prat V (2015) Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds

Clean the injection site with alcohol, pinch the skin to create a fold of tissue, insert the needle at a 45-90 degree angle, inject slowly, and withdraw the needle