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Microarray and transcriptomic analyses have shown that GHK-Cu modulates the expression of hundreds of genes in human fibroblasts, with research interest in understanding which regulatory networks are engaged

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Sedlak TW, Paul BD, Parker GM, Hester LD, Snowman AM, Taniguchi Y, Kamiya A, Snyder SH, Sawa A

TRX1 is known to stabilize HIF1, facilitate its nuclear translocation, and increase the transcription of hypoxia genes [76]