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Semaglutide works by mimicking the gut hormone GLP1, which tells your brain youre full even when you eat less

However, recent studies in patients who underwent RYGB found that estimates of insulin sensitivity with fasting glucose and insulin (including HOMA-IR) or glucose response to an oral glucose load do not readily correlate with direct measures of insulin sensitivity (90), suggesting that there could be methodological concerns about using estimates of insulin sensitivity to compare the efficacy of these two surgeries

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Glucagon plays a role in keeping blood glucose levels normal by signaling the liver to release stored glucose

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