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Notably, GLP-1 significantly suppressed plasma pancreatic polypeptide concentrations following the first meal, 68 but this effect diminished substantially after the second test meal, 72 suggesting autonomic nervous system adaptation to continuous GLP-1 administration

The patient then fasts, consuming only noncaloric and noncaffe inated beverages for 72 hours

Importantly, these effects occur without changes in food intake, indicating metabolic rather than anorectic mechanisms

Fatigue, headaches, muscle cramps, and worsened nausea are common signs of electrolyte depletion