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Meanwhile, long-term intracellular accumulation of platinum ions and persistent oxidative stress can activate the senescence program of renal tubular epithelial cells, induce cell cycle arrest and Senescence-Associated Secretory Phenotype (SASP), release a large number of pro-inflammatory and pro-fibrotic factors through paracrine effects, further amplify the local inflammatory response, and activate the proliferation and activation of renal interstitial fibroblasts (Nakao et al
The goal is to avoid repeatedly injecting the exact same location because doing so can cause skin irritation, scarring, or tissue damage (think: lumps) over time
The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses
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GLP-1RAs were also efficacious as adjunctive therapies [e.g., in combination with nicotine replacement therapies (NRTs)]
People with existing medical conditions (consult your doctor first)
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