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Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks

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doi: 10.1056/NEJMp2400978 Summary Keywords GIP, GLP-1, GLP-1RA, tirzepatide, diabetes, obesity, cardiovascular disease Citation Liu QK (2024) Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists

Eli Lilly is conducting multiple phase 3 trials

Bottom Line Period changes while on GLP-1s are real, and plenty of women experience them

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