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In mouse peritonitis, KPV reduced neutrophil accumulation and showed anti-inflammatory activity independent of classic melanocortin receptors, likely via inhibition of IL-1driven pathways rather than cAMP signalingevidence for KPVs MC-receptor-independent action

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Many women with PCOS have elevated levels of luteinizing hormone (LH), which is a hormone involved with ovulation

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White adipose tissue in these mice had a unique immunophenotype, with increased proinflammatory macrophages and dysfunctional Tregs, suggesting a mechanism for adiposity distinct from those of typical obesity models