semaglutide vs tirzepatide weight loss studies vs. for Tirzepatide vs Semaglutide: Which Medication

Robert Popovian and Conner Mertens dive into the problematic practices of Pharmacy Benefit Managers (PBMs) that prioritize profits over patient access to affordable medications

Zhao LR, Xing RL, Wang PM, Zhang NS, Yin SJ, Li XC, Zhang L

The short version: Melanotan I (Afamelanotide) has received FDA/EMA approval for a specific medical condition (erythropoietic protoporphyria) and is more selective for skin pigmentation

Orforglipron, an oral small-molecule GLP-1 receptor agonist, in early type 2 diabetes

GLP-1R in its inactive apo-state is constantly moving but prefers to adopt a closed ECD conformation in absence of peptide binding (55)

Severo JS, et al