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Membrane-tethered ligands are effective probes for exploring class B1 G protein-coupled receptor function

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GIP-induced insulin secretion and consequences for the incretin effect Endogenous GIP affects postprandial plasma glucose excursions and insulin secretion more than endogenous GLP-1, but the hormones contribute additively to postprandial glucose regulation in healthy individuals [4]

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On tirzepatide, the same principle applies