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The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity

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Clin Res Cardiol 107(7):578585

Reconstitute MOTS-c in smaller volumes you can use within a week, or aliquot the reconstituted vial into freezer-safe containers for -20 C storage (2-3 months)