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Among the widely studied pathways for stimulating the browning of white adipocytes are the actions of norepinephrine, which is released by sympathetic nerve terminals and binds with -adrenergic receptors mainly 3 -AR found on the surface of adipocytes to carry out its functions (Otton et al., 2021)
Asian Pac J Cancer Prev (2013) 14(9):5199205
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133 Because tumor cells exchange intracellular glutamate for extracellular cystine through SLC7A11, intracellular glutamate is consumed, which causes cells to absorb more Gln and activate glutaminase to supplement intracellular glutamate, making cells with high expression of SLC7A11 become Gln-dependent
Kenney, J
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