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Uremic toxins such as indoxyl sulfate and p-cresyl sulfate, derived from microbial metabolism, impair kidney function and disrupt neurocognitive health via oxidative stress and neuroinflammation, highlighting the interconnectedness of these systems

Metabolites Lys-Tyr ( R = 0.79, P = 0.004) and Besifovir ( R = 0.90, P = 0.0001) were positively correlated with diarrhea incidence, whereas benzoic acid ( R = 0.65, P = 0.03) and O-arachidonoyl ethanolamine ( R = 0.84, P = 0.001) were negatively correlated (Supplementary Figure 1)

doi: 10.1016/j.kint.2022.07.034 13 ProudfootDSkepperJNHegyiLBennettMRShanahanCMWeissbergPL