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Evidence includes: Stimulation of endothelial and keratinocyte migration Enhanced blood vessel density in wound healing models Promotion of stem cell differentiation toward repair cell lineages Low molecular weight enabling tissue penetration over long distances Unlike growth factors that bind to extracellular matrix, TB-500s mobility allows systemic distribution to multiple injury sites

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showed that 500 M MnCl 2 exposure increased caspase 3 cleavage and reduced cell viability in PC12 cells (Yagyu et al., 2020)

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