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Given the narrative nature of this review, a double-blind screening process was not applied, which is acknowledged as a limitation

Gut-immune axis Dysbiosis and endotoxemia amplify systemic inflammation and pain sensitivity (gut-brain axis) Sleep/circadian rhythm Deprivation elevates pain perception and reduces GH pulsatility, which is essential for tissue repair

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Modulating eryptosis, whether by inducing or inhibiting the process, could help regulate erythrocyte survival to prevent premature cell loss or promote the removal of damaged erythrocytes, thereby contributing to the proper balance of blood cell counts

[2] [3] Taking berberine with food may reduce gastrointestinal side effects