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Some participants lost over 30%

While increases in GH and IGF-1 are beneficial during adolescence, studies relating the GH and IGF-1 status to longevity provide inconsistent evidence as to whether decreased or high levels of these hormones are beneficial or detrimental to longevity

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Insulin-like growth factor 1 (IGF-1), known as a cytoprotective hormone, mainly synthesized in liver, regulates cell senescence, survival, proliferation, and so on 8,9,10

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