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481,482 (4) A fourth targeted drug approach is the activation of PPAR- in mature adipocytes that then induces altered expression of several genes (increased GLUT4 and adiponectin expression, along with decreased TNF-, IL-6 and leptin expression) involved in the insulin signaling cascade, thereby improving insulin sensitivity

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Across the four trial stages, this accounts for 97.6% to 100% of patients in the said group in contrast to 86.7% to 95.3% recorded among those not on antidepressants

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