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J Dairy Res

When T2D-like disease model mice are fed a high-calorie diet, the accumulation of oxidative stress in adipose tissue and senescence-associated alterations, including increases in p53 levels, proinflammatory cytokine levels, and senescence-associated beta-galactosidase activity, are observed

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When NF-kB interacts with IkB in the cytoplasm, it is unable to enter the nucleus and bind to the promotor region of proinflammatory genes

Wang N, Lan D, Chen W, Matsuura F, Tall AR

AOD 9604 best result: 2.8kg average weight loss over 12 weeks in the 1mg oral dosing group, versus 0.8kg for placebo