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Indeed, excess mROS activates the NLRP3 inflammasome by upregulating IL-1 and IL-18 levels, further exacerbating inflammatory reactions within these cells (51, 93)

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Additionally, the downregulated proteins in gallstone bile showed enrichment in bile acid and bile salt transport ( p adjusted = 0.004), which included AKR1C1, ABCC2, ABCB11, and ATP8B1

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