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Vitamin C supplementation Adults: Oral Vitamin C 1000 mg/d in divided doses for at least one week, then 300-500 mg/d for a further week, followed by the recommended daily allowance

555 However, an evolutionarily conserved amino acid substitution at the binding site for VHL in HIF-2 results in a 2-3-fold decrease in its binding affinity compared to HIF-1

Consider expanding the measurement panel to include upstream or downstream markers in the same pathway

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Endocrinology, 112 (2), 442-448