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Additionally, Semaglutide may cause mild dehydration, which can also contribute to headaches

Updated February, 2022

In people with both type 2 diabetes and obesity, an indirect comparison drawing on the separate SURMOUNT-2 (NCT04657003) and STEP 2 (NCT03552757) trials, rather than a single head-to-head study, reported weight reduction of up to 15.7% with tirzepatide and 10.6% with semaglutide 2.4 mg

A meta-analysis of the efficacy of glucagon-like peptide-1 receptor agonists on nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

Notably, among the proteins associated with folate metabolism, MPO exhibited a significant increase during gallstone development and mucus layer thickening in a mouse model (39)

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