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The protein expression and activity assays of the D23A mutant were performed as described for the U46C mutant

And aspirin inhibits its own activity by acetylating the K384, K394, and K414 residues of cGAS

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[Abstract] Cell Signal

Overexpression of GSH and GPx has been linked to resistance in cisplatin and doxorubicin-treated cancers, while Nrf2 activation enhances the antioxidant response, promoting drug resistance [80]