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It is the simultaneous drift of dozens of biological systems away from their optimal states over decades

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They may work reasonably well for GI issues or systemic support, but bioavailability is less predictable

Targeted Reduction of Stubborn Fat Deposits: AOD-9604 appears especially effective at mobilizing fat from areas resistant to traditional diet and exercise interventions

One method of restoring normal intestinal microbiota is fecal microbiota transplantation (FMT)