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Hunt SC et al

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No difference in CV death was observed

What the new mechanism is: GLP-1 : appetite regulation, improved glucose control GIP : incretin effects that may augment metabolic benefits Glucagon receptor activity : potentially influences energy expenditure and fat metabolism (while requiring careful balancing of tolerability and metabolic effects) What results look like (so far): Phase 2 (48 weeks) published in NEJM showed substantial mean weight reductions (with higher doses showing very large effects)

Eating balanced meals with adequate protein and healthy fat slows carbohydrate absorption and prevents rapid blood sugar fluctuations that could trigger hypoglycemia during treatment

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