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Topical immunomodulators such as tacrolimus and pimecrolimus attenuate the production of proinflammatory cytokines by inhibiting T cell activity, thereby enhancing melanocyte migration and pigmentation in vitiligo patients (Ormerod 2005)

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Following the 6.5 month experimental period, mice showed no evidence of side effects from long term supplementation of epitalon

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ICIs work by blocking the interactions between immune checkpoints such as CTL-associated protein 4 (CTLA-4), programmed cell death-1 (PD-1), and programmed cell death ligand-1 (PD-L1) and their ligands, which releases the inhibitory brakes of T cells and results in the robust activation of immune responses (Fig